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Research explainer · 49 seconds

Understanding triple-receptor agonists

This video discusses retatrutide, an investigational compound sometimes inaccurately called GLP-3. It is a research explanation, not verification of any product.

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Audio and burnt-in captions are included in the video. If playback is unavailable, download the 49-second MP4.

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What is GLP-3? It is an informal nickname for a triple agonist called retatrutide. An agonist activates a receptor: one way cells receive chemical signals. This compound activates three receptor types: GLP-1, GIP, and glucagon. These hormone pathways help regulate appetite, blood glucose, and energy balance. Researchers are studying what happens when one molecule acts on all three. Clinical trials have reported weight loss and changes in blood-glucose control, but results depend on the study and participant. It remains investigational. Side effects occur, and long-term safety is still being evaluated. Trial findings do not verify any retailer's product.